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Approximately half of people with type 1 or type 2 diabetes experience peripheral neuropathy-;weakness, numbness, and pain, primarily in the hands and feet. The condition occurs when high levels of sugar circulating in the blood damage peripheral nerves. Now, working…
In a recent study published in Scientific Reports, researchers developed a computational workflow based on molecular dynamic (MD) simulations and artificial neural network (ANN) to assess the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein receptor-binding domain (RBD)-human…
An estimated ninety percent of deaths from breast cancer are due to complications resulting from metastasis, a process in which cancer cells break away from where they first formed, travel through the blood or lymph circulatory system, and form new,…
In a recent study posted to the bioRxiv* preprint server, researchers explored the effects of mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) on viral transmission. Study: The effect of previous SARS-CoV-2 infection and…
In a recent study posted to the bioRxiv* preprint server, researchers investigated the main source of editing of the mpox (MPX) virus (MPXV) genome. Study: APOBEC3F is the main source of editing identified during the 2022 outbreak of human monkeypox virus.…
A recent study published in the journal Nature reported the co-aggregation of medin, a fragment of lactadherin, with vascular amyloid-β in Alzheimer’s disease (AD). Amyloidosis is caused by systemic or local accumulation of misfolded, insoluble, and aggregated proteins. So far,…
In a recent study posted to the bioRxiv* preprint server, researchers from Nigeria and the United Kingdom (U.K.) analyzed mpox virus genomes and found that divergent lineages of the mpox virus exhibiting human-to-human transmission existed in the Nigerian population before…
In a recent article published in Science Translational Medicine, researchers developed a novel pan-vaccine antigen (Span)-based subunit vaccine against coronavirus disease 2019 (COVID-19). Using a mouse model, they also demonstrated that this vaccine formulation conferred protection against multiple clades of…
A fundamental principle of molecular biology governs how proteins are made within the cell, which happens in two stages called transcription and translation. During transcription, information stored in DNA is copied into messenger RNA (mRNA). Then during translation, the ribosomes…
Scientists have identified an immunogenic epitope at the furin cleavage site of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that induces robust antibody responses in coronavirus disease 2019 (COVID-19) patients. In their study published in the journal eBioMedicine, the researchers…
