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In a recent study posted to bioRxiv*, researchers designed a nanoparticle (NP)-conjugated toll-like receptor 9 (TLR9) agonist to improve the adjuvanticity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines. Subunit vaccines contain protein antigens and one or more adjuvants,…
In a recent study posted to the medRxiv* preprint server, researchers at Oregon Health & Science University assessed the impact of the duration between coronavirus disease 2019 (COVID-19) infection and vaccination on immunity against infection. As the spread of severe…
There has been an increase in the development of coronavirus disease 2019 (COVID-19) vaccines in several countries due to the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The RNA vaccine platform is a next-generation platform that comprises…
In a recent article published in Science Translational Medicine, researchers developed a novel pan-vaccine antigen (Span)-based subunit vaccine against coronavirus disease 2019 (COVID-19). Using a mouse model, they also demonstrated that this vaccine formulation conferred protection against multiple clades of…
This new article publication from Acta Pharmaceutica Sinica B, discusses a fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development. The authors of…
Nano-sized membrane bubbles known as extracellular vesicles activate the immune system in mice and seem to render their tumors sensitive to a type of immunotherapy drug called a checkpoint inhibitor. This is according to a new study published in Cancer…
In a recent study published in the journal PLOS Pathogens, researchers investigated the mechanisms through which the human common cold Betacoronavirus OC43 (HCoV-OC43) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibit the formation of stress granules. Study: Nsp1 proteins…
In a recent study posted to the medRxiv* preprint server, researchers from Germany conducted a population-based surveillance study to ascertain the etiology of community-acquired pneumonia (CAP) during the re-emergence of viral and bacterial respiratory diseases after the relaxation of coronavirus…
In a recent study posted to the Research Square* preprint server, researchers reported the waning of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the six months following a booster dose of the messenger ribonucleic acid (mRNA) coronavirus…
In two separate studies, researchers demonstrate how synthetic biology can be used to tackle a difficult issue in cancer immunotherapy: the way immunotherapy-related approaches focused on short-term killing of tumor cells may fail to eradicate tumors because growth of tumors…
