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Tag Antigen

Health

Study demonstrates how pan-sarbecovirus ORF7a protein plays a role in evading host immunity

In a recent study published in Immunity, researchers demonstrated how sarbecovirus family down-regulates major histocompatibility complex-I (MHC-I) surface expression to evade cellular immunity. Study: Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins. Image Credit: Corona Borealis Studio/Shutterstock…

GT
September 26, 2022

Health

DNA nets effectively target the spike protein and detect COVID-19 virus at very low levels

Tiny nets woven from DNA strands can ensnare the spike protein of the virus that causes COVID-19, lighting up the virus for a fast-yet-sensitive diagnostic test – and also impeding the virus from infecting cells, opening a new possible route…

GT
September 24, 2022

Health

Study explores the effect of age-associated B cells on COVID-19 vaccine-induced immunity

In a recent study posted to the medRxiv* preprint server, a team of researchers explored the effect of immune checkpoint blockade (ICB)-induced expansion of age-associated B cells (ABCs) on coronavirus disease 2019 (COVID-19) vaccine-derived humoral immunity in patients with cancer…

GT
September 22, 2022

Health

Vaccination-induced responses for Omicron subvariant neutralization

In a recent study posted to the medRxiv* preprint server, researchers summarized existing data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant’s sub-variant (BA.1, BA.1.1, BA.2, BA.2.12.1, BA.3, and BA.4/5) neutralization. They also performed a comparative assessment of…

GT
September 20, 2022

Health

Molecular engineered low-cost highly effective RBD-based COVID vaccine

In a recent study posted to the bioRxiv* preprint server, an international team of researchers developed a second-generation severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domain (RBD) antigen (RBD-J6) by molecular engineering with two additional amino acid (aa)…

GT
September 20, 2022

Health

SARS-CoV-2 N escape mutations do not affect rapid antigen testing

The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to over 6.4 million deaths, with fresh cases continuing to emerge. With the widespread vaccination drives, the spread of the virus was expected to decrease. The occurrence of breakthrough infections and…

GT
September 16, 2022

Health

Study evaluates how rapid tests will perform when challenged with future SARS-CoV-2 variants

The availability of rapid antigen tests has significantly advanced efforts to contain the spread of COVID-19, but every new variant of concern raises questions about whether diagnostic tests will still be effective. A new study published in Cell attempts to…

GT
September 16, 2022

Health

Mechanism of action of different COVID-19 vaccines

In a recent study posted to the bioRxiv* preprint server, researchers at the University of Tuebingen and Imperial College London assessed humoral and cellular immune responses elicited by the recombinant adenoviral vector (rAdVV)- and messenger ribonucleic acid (mRNA)-based coronavirus disease…

GT
September 15, 2022

Health

COVID-19 risk substantially reduced in seniors who receive 4th mRNA booster

In a recent study published in the Annals of Internal Medicine, researchers in Singapore estimated the effectiveness of the second booster (fourth dose) vaccination with messenger ribonucleic acid (mRNA) vaccines against symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections…

GT
September 14, 2022

Health

Altered T-cell response in hemodialysis patients following third COVID-19 vaccine dose

The global impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of the coronavirus disease 2019 (COVID-19) pandemic, has been immense, especially for the healthcare sector and economy. To date, the pandemic has claimed more than…

GT
September 14, 2022

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