Tag Lymphocyte

Health

SARS-CoV-2 infection enhances vaccine-induced immunological memory against spike protein

In a recent study published in the journal Science Translational Medicine, researchers in France perform a longitudinal follow-up assessment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein-specific immunological memory among unvaccinated and vaccinated coronavirus disease 2019 (COVID-19) convalescents,…

GT
March 23, 2023

Health

Tetravalent COVID vaccine provides broad antibody responses against SARS-CoV-2 variants in animal model

*Important notice: bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information. In a recent study posted to the bioRxiv* preprint server, researchers in…

GT
March 22, 2023

Health

An emerging target for chronic kidney disease treatment – DNA-PKcs

Around 10% of the global population is affected by chronic kidney disease (CKD). The risk of CKD progressing into end-stage renal disease (ESRD) is exceptionally high, which requires dialysis or kidney transplantation. At present, there is no effective treatment for…

GT
March 15, 2023

Health

Critical COVID-19 infection characterized by a shift from naïve T cell phenotypes to an expansion of cytotoxic CD4+ T lymphocyte subsets

*Important notice: medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information. In a recent study posted to the medRxiv* preprint server, researchers immunophenotyped…

GT
February 28, 2023

Health

Roadmap outlines a framework for moving COVID-19 vaccines forward

In a recent report published in Vaccine, researchers presented the coronavirus vaccines research and development roadmap (CVR) to promote the development of broadly protective coronavirus disease 2019 (COVID-19) vaccines. Study: A Research and Development (R&D) Roadmap for Broadly Protective Coronavirus…

GT
February 24, 2023

Health

Researchers devise a novel potential IBD treatment strategy that eliminates pathogenic T cells and encourages the proliferation of regulatory T cells

In a recent study published in Science Immunology, researchers investigated the CAMCI (combination of cell activation and metabolic checkpoint inhibition) strategy as an immunotherapeutic option for inflammatory bowel disease (IDB). Study: CD4+ T cell activation and concomitant mTOR metabolic inhibition…

GT
January 31, 2023

Health

Study suggests robust lung mucosal immunity against SARS-CoV-2 can be better achieved through hybrid immunity, as opposed to peripheral vaccination alone

In a recent study posted to the bioRxiv* preprint server, researchers characterized immunological responses by pulmonary mucosal tissues post-coronavirus disease 2019 (COVID-19) vaccination and/or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, to assess the impact of hybrid immune protection…

GT
January 30, 2023

Health

What are the major findings of long COVID research?

In a recent review published in Nature Reviews Microbiology, researchers explored existing literature on long coronavirus disease (COVID). They highlighted key immunological findings, similarities with other diseases, symptoms, associated pathophysiological mechanisms, and diagnostic and therapeutic options, including coronavirus disease 2019…

GT
January 17, 2023

Health

Study reveals why some germinal centers persist for months rather than weeks

If B cells are the munitions factories of the immune system, manufacturing antibodies to neutralize harmful pathogens, then the tiny biological structures known as germinal centers are its weapons-development facilities. Formed in response to infection and vaccination, these microscopic training…

GT
December 23, 2022

Health

Could mRNA vaccines triumph over other viral infections in humans and domestic animals?

The global success of messenger ribonucleic acid (mRNA) vaccines in mitigating the severity of the coronavirus disease 2019 (COVID-19) has motivated researchers to explore the promising potential of mRNA technology against an array of viruses that infect humans and animals.…

GT
November 29, 2022

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