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A recent study published in the Journal of Fungi used a novel OrbitrapTM high-resolution mass spectrometric technology coupled with liquid chromatography to identify geographically different clades of Candida auris (C. auris) isolates. This proof-of-concept methodology could accurately detect C. auris in the microbiology laboratory.…
Human milk (HM) is considered the gold standard for the nutrition of infants, as it provides several dietary benefits to the mother-infant dyads for both the short and long term. HM comprises various types of cells including leukocytes and epithelial…
Imidazole dipeptides (IDPs), which are abundant in meat and fish, are substances produced in the bodies of various animals, including humans, and have been reported to be effective in relieving fatigue and preventing dementia. However, the physiological mechanism by which…
The January 2023 issue of SLAS Discovery contains a collection of four full-length articles and one technical brief covering cancer research, high-throughput screening (HTS) assay development and other drug discovery exploration. This month’s featured article, “A high-throughput MALDI-TOF MS biochemical…
Pulmonary arterial hypertension (PAH) is a rare and incurable disease of the lung arteries that causes early death. In PAH, excess scar tissue and thickening of lung blood vessels occur as the result of increased cell “biomass.” These changes obstruct…
Previous studies have described the importance of analyzing dietary patterns, rather than analyzing the nutritional content of individual food products, to better understand overall dietary quality, promote better health status, and ultimately mitigate disease risk. A recent Clinical Nutrition study identifies blood…
A new method to study specific changes in DNA after replication has been published as a technical report in Nature Cell Biology. Researchers developed a highly sensitive, quantitative mass spectrometry-based approach, called iDEMS (isolation of DNA by EdU labelling for…
In a recent study published in Nature Medicine, researchers systematically investigated the genetic makeup of nearly 20,000 women and men in terms of >900 metabolites. Study: Rare and common genetic determinants of metabolic individuality and their effects on human health.…
A blood test taken at the time of Covid-19 infection could predict who is most likely to develop long Covid, suggests a new small-scale study led by UCL researchers. The study, published in Lancet eBioMedicine, analyzed proteins in the blood…
Can you provide an overview of mass spectrometry? Mass spectrometry is a technique that allows us to measure the mass of individual particles and molecules. A mass spectrometer instrument generates an isotopic signature, a kind of fingerprint, that can identify…
