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Microbiomes have taken on major importance as producers and modulators of the host metabolism and homeostatic machinery. In a new study, researchers at the University of Calgary, Canada, explored the metabolomes of mice exposed to different types of microbes to…
A shot of a liver-produced hormone called FGF21 sobered up mice that had passed out from alcohol, allowing them to regain consciousness and coordination much faster than those that didn’t receive this treatment, UT Southwestern researchers report in a new…
A study published in Scientific Reports highlights that gout can increase the risk of Alzheimer’s disease and Parkinson’s disease in younger or overweight individuals. The study was conducted in a representative Korean population. Study: Longitudinal follow-up study of the association…
A recent study published in the journal Trends in Endocrinology and Metabolism discusses recent findings linking satiety to the gut microbiome. Study: Influence of the gut microbiota on satiety signaling. Image Credit: FOTOKITA / Shutterstock.com The microbiome and metabolism A growing body…
Space travel has always tested the human body by the effects of the new conditions of altered gravity on biological systems. It has long been known that continuous exposure to microgravity conditions human physiology and causes effects that compromise muscular,…
In a recent study published in the eBioMedicine, researchers examined the effect of serum levels of 20 amino acids in a mother during pregnancy on offspring birthweight in a two-sample summary data Mendelian randomization (MR) framework. Study: Causal effects of…
A small but significant metabolic difference between human and mouse lung tumor cells, has been discovered by Weill Cornell Medicine researchers, explaining a discrepancy in previous study results, and pointing toward new strategies for developing cancer treatments. The work, published…
In a recent study published in JAMA Network Open, researchers compare the pharmacokinetics (PK) and pharmacodynamics (PD) of oral Δ9-tetrahydrocannabinol (Δ9-THC)-dominant and cannabidiol (CBD)-dominant cannabis extracts that contained the same Δ9-THC dose (20 mg). Study: Assessment of Orally Administered Δ9-Tetrahydrocannabinol…
*Important notice: Research Square publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information. Parkinson’s disease (PD) is a neurodegenerative disorder that leads to the…
Takeaki Ozawa and his team from the University of Tokyo reveal the metabolic reactions upon activating an enzyme called Akt2. In doing so, they reveal the inner workings of insulin-regulated metabolism. The findings lead the way for Akt2-targeting therapeutics for…
