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Metabolic pathways consist of a series of biochemical reactions in cells that convert a starting component into other products. There is growing evidence that metabolic pathways coupled with external stress factors influence the health of cells and tissues. Many human…
A new study in the journal Nature Medicine analyzes longitudinal and cross-sectional changes in blood analytes associated with variations in body mass index (BMI). Study: Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention. Image Credit:…
During the perinatal period, the maternal diet and behavior affect the developmental trajectory of the offspring. Several studies have indicated maternal depression and obesity enhance the risk of neuropsychiatric disease in offspring. Recently, scientists reviewed the mechanisms associated with the maternal…
A recent study at the University of Jyväskylä (Finland) compared the gut microbiota and gut-derived metabolites between healthy controls and individuals with fatty liver. The results revealed that certain microbial metabolites are associated with liver fat content. The fact that…
New research from the University of Missouri School of Medicine has established a link between western diets high in fat and sugar and the development of non-alcoholic fatty liver disease, the leading cause of chronic liver disease. The research, based…
Researchers have revealed the modulatory effect of the anti-inflammatory metabolite itaconate on T helper and T regulatory cells, which may lead to new therapeutic approaches to treating some autoimmune diseases. Autoimmune diseases occur when the immune system attacks its own…
Microbiomes have taken on major importance as producers and modulators of the host metabolism and homeostatic machinery. In a new study, researchers at the University of Calgary, Canada, explored the metabolomes of mice exposed to different types of microbes to…
Around 10% of the global population is affected by chronic kidney disease (CKD). The risk of CKD progressing into end-stage renal disease (ESRD) is exceptionally high, which requires dialysis or kidney transplantation. At present, there is no effective treatment for…
A recent study published in the journal Trends in Endocrinology and Metabolism discusses recent findings linking satiety to the gut microbiome. Study: Influence of the gut microbiota on satiety signaling. Image Credit: FOTOKITA / Shutterstock.com The microbiome and metabolism A growing body…
Human milk (HM) is considered the gold standard for the nutrition of infants, as it provides several dietary benefits to the mother-infant dyads for both the short and long term. HM comprises various types of cells including leukocytes and epithelial…
