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Tag Omicron

Yeast display used to generate SARS-CoV-2 RBD-specific nanobodies

In a recent study published in iScience, researchers engineered biparatopic nanobodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Biparatopic nanobodies targeting the receptor binding domain efficiently neutralise SARS-CoV-2. Image Credit: Juan Gaertner/Shutterstock Background Despite the rapid development of…

Omicron reduces host antibody response by lower B-cell antigenicity

Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), numerous viral variants have emerged. These variants have shown enhanced transmissibility, virulence, and immune evasion capacity. The most recent of…

Antibody escape mutations of SARS-CoV-2 BA.2.75

The coronavirus disease 2019 (COVID-19) pandemic caused great havoc worldwide, directly through its impact on human health and because of the non-pharmaceutical measures implemented to mitigate its spread. After one year of lockdowns, social distancing, mask-wearing, and closures of businesses…

What are the challenges of COVID-19 vaccination and herd immunity?

A recent study published in The Clinical Respiratory Journal reviewed the challenges of coronavirus disease 2019 (COVID-19) vaccination and herd immunity. Study: Challenges of vaccination and herd immunity in COVID-19 and management strategies. Image Credit: Komsan Loonprom/Shutterstock Globally more than 6.5…

Spike-specific memory B cells develop resilience to SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, researchers explored the cross-reactivity, avidity, and kinetics of memory B-cells and serum antibodies in vaccinated and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected individuals. Study: Maturation of SARS-CoV-2 Spike-specific…

What is the risk of Omicron infection in pregnant women?

In a recent study published in BMJ Medicine, researchers evaluated the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnant women during the Omicron predominance period in the United Kingdom (UK). Study: Severity of maternal SARS-CoV-2 infection and…