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Study may have solved a mystery surrounding Crohn’s disease

A new study may have solved a mystery surrounding Crohn’s disease, a type of inflammatory bowel disease in which immune defenses meant to attack invading microbes instead mistakenly target the body’s own digestive tract. Norovirus, a common infection that causes…

Yeast display used to generate SARS-CoV-2 RBD-specific nanobodies

In a recent study published in iScience, researchers engineered biparatopic nanobodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Biparatopic nanobodies targeting the receptor binding domain efficiently neutralise SARS-CoV-2. Image Credit: Juan Gaertner/Shutterstock Background Despite the rapid development of…

Omicron reduces host antibody response by lower B-cell antigenicity

Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), numerous viral variants have emerged. These variants have shown enhanced transmissibility, virulence, and immune evasion capacity. The most recent of…

Antibody escape mutations of SARS-CoV-2 BA.2.75

The coronavirus disease 2019 (COVID-19) pandemic caused great havoc worldwide, directly through its impact on human health and because of the non-pharmaceutical measures implemented to mitigate its spread. After one year of lockdowns, social distancing, mask-wearing, and closures of businesses…