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O-linked sialoglycans affect SARS-CoV-2 spike cleavage

In a recent study posted to the bioRxiv* preprint server, researchers from Spain, the United Kingdom, and the United States used chemical tools to uncover the molecular details of glycan-mediated modulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike…

Study suggests entry of SARS-CoV-2 requires an acidic pH

In a recent study published in PNAS, researchers carried out real-time single-virion tracking in three dimensions to study the mechanisms and requirements of membrane attachment and fusion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with the host cell. Study:…

Auranofin inhibits SARS-CoV-2 replication

The rapid outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused the ongoing coronavirus disease 2019 (COVID-19) pandemic has claimed more than 6.5 million lives worldwide. Although the majority of the SARS-CoV-2 infected individuals experienced mild to moderate symptoms and…